Protein Details: Calcium release-activated calcium channel protein 1

Protein ID

ICDB_Pro_1754

Protein Name

Calcium release-activated calcium channel protein 1

Gene Name

orai1 tmem142a zgc:109721

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

222 amino acids

AlphaFoldDB

AF-Q6TLE6-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.

Sequence

MKMSRSEHSLQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDTNHDYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAGVVLLCWVKFLPIKPKGQKNGTVSAGVAAAITSTSIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELEELEDLQNELDHREEVSTLQSPGSLYP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1073/pnas.0407241101

RefSeq

NP_991163.1